Santhanam migrated to big screen from small screen. He made his debut in Simbhu starrer Manmadhan. After this, he continued to act in comedian roles.
He donned an important role in the film Siva Manasula Sakthi. After this he got a prominent place in Tamil cinema. At this juncture Vadivelu quit acting. Because of this Santhanam was most sought after comedian.
Santhanam who donned comedian roles with others made his debut in the lead role in a film titled Kanna Laddu Thinna Aasaiya. After this, he continued to don lead roles in the films Vallavanukku Pullum Aayudham and Inime Ippadithan. Now he has donned the lead role in a film titled Dhillukku Dhuddu. This film is to be released soon.
At this juncture, Santhanam has been approached for Ajith’s 57th film but he did not want to essay the role of a comedian. Santhanam while speaking said, “Everyone will wish to go to the next step in their life. There are lots of comedy films but I don’t want to continue in this for a long time.” Santhanam did not accept the comedian role in Vijay’s Theri. Moreover he has avoided Ajith’s film because the callsheet for his lead roles should not be affected.